For severe manic episodes, traditional antipsychotic medications (such as Haldol, Loxapine, or Thorazine) as well as newer antipsychotic drugs — also called atypical antipsychotics — may be necessary. Cariprazine (Vraylar) is a newly approved antipsychotic to treat manic or mixed episodes. Aripiprazole (Abilify), asenapine (Saphris), clozapine (Clozaril), olanzapine (Zyprexa), quetiapine (Seroquel), risperidone (Risperdal), and ziprasidone (Geodon) are often used, and many other drugs are available. The antipsychotic lurasidone (Latuda) is approved for use — either alone or with lithium or valproate (Depakote) — in cases of bipolar I depression. Antipsychotic medicines are also sometimes used for preventive treatment.